SARS-CoV-2 and COVID-19 in older adults: what we may expect regarding pathogenesis, immune responses, and outcomes
Identifieur interne : 000274 ( 2020/Analysis ); précédent : 000273; suivant : 000275SARS-CoV-2 and COVID-19 in older adults: what we may expect regarding pathogenesis, immune responses, and outcomes
Auteurs : Janko Nikolich-Zugich [États-Unis] ; Kenneth S. Knox [États-Unis] ; Carlos Tafich Rios [États-Unis] ; Bhupinder Natt [États-Unis] ; Deepta Bhattacharya [États-Unis] ; Mindy J. Fain [États-Unis]Source :
- GeroScience [ 2509-2715 ] ; 2020.
Abstract
SARS-CoV-2 virus, the causative agent of the coronavirus infectious disease-19 (COVID-19), is taking the globe by storm, approaching 500,000 confirmed cases and over 21,000 deaths as of March 25, 2020. While under control in some affected Asian countries (Taiwan, Singapore, Vietnam), the virus demonstrated an exponential phase of infectivity in several large countries (China in late January and February and many European countries and the USA in March), with cases exploding by 30–50,000/day in the third and fourth weeks of March, 2020. SARS-CoV-2 has proven to be particularly deadly to older adults and those with certain underlying medical conditions, many of whom are of advanced age. Here, we briefly review the virus, its structure and evolution, epidemiology and pathogenesis, immunogenicity and immune, and clinical response in older adults, using available knowledge on SARS-CoV-2 and its highly pathogenic relatives MERS-CoV and SARS-CoV-1. We conclude by discussing clinical and basic science approaches to protect older adults against this disease.
Url:
DOI: 10.1007/s11357-020-00186-0
PubMed: NONE
PubMed Central: 7145538
Affiliations:
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Box 249221, 1501 N. Campbell Ave, Tucson, AZ 8524 USA</nlm:aff><wicri:noCountry code="subfield">AZ 8524 USA</wicri:noCountry></affiliation></author><author><name sortKey="Knox, Kenneth S" sort="Knox, Kenneth S" uniqKey="Knox K" first="Kenneth S." last="Knox">Kenneth S. 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Fain</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.134563.6</institution-id><institution-id institution-id-type="ISNI">0000 0001 2168 186X</institution-id><institution>University of Arizona Center on Aging,</institution><institution>University of Arizona College of Medicine-Tucson,</institution></institution-wrap>P.O. Box 249221, 1501 N. Campbell Ave, Tucson, AZ 8524 USA</nlm:aff><wicri:noCountry code="subfield">AZ 8524 USA</wicri:noCountry></affiliation><affiliation wicri:level="2"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="GRID">grid.134563.6</institution-id><institution-id institution-id-type="ISNI">0000 0001 2168 186X</institution-id><institution>Division of Geriatrics, General and Palliative Medicine, Department of Medicine,</institution><institution>University of Arizona College of Medicine-Tucson,</institution></institution-wrap>Tucson, AZ 85724 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Arizona</region></placeName><wicri:cityArea>Tucson</wicri:cityArea></affiliation></author></analytic><series><title level="j">GeroScience</title><idno type="ISSN">2509-2715</idno><idno type="eISSN">2509-2723</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="Par1">SARS-CoV-2 virus, the causative agent of the coronavirus infectious disease-19 (COVID-19), is taking the globe by storm, approaching 500,000 confirmed cases and over 21,000 deaths as of March 25, 2020. While under control in some affected Asian countries (Taiwan, Singapore, Vietnam), the virus demonstrated an exponential phase of infectivity in several large countries (China in late January and February and many European countries and the USA in March), with cases exploding by 30–50,000/day in the third and fourth weeks of March, 2020. SARS-CoV-2 has proven to be particularly deadly to older adults and those with certain underlying medical conditions, many of whom are of advanced age. Here, we briefly review the virus, its structure and evolution, epidemiology and pathogenesis, immunogenicity and immune, and clinical response in older adults, using available knowledge on SARS-CoV-2 and its highly pathogenic relatives MERS-CoV and SARS-CoV-1. We conclude by discussing clinical and basic science approaches to protect older adults against this disease.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Alsaad, Ko" uniqKey="Alsaad K">KO Alsaad</name></author><author><name sortKey="Hajeer, Ah" uniqKey="Hajeer A">AH Hajeer</name></author><author><name sortKey="Al Balwi, M" uniqKey="Al Balwi M">M Al Balwi</name></author><author><name sortKey="Al Moaiqel, M" uniqKey="Al Moaiqel M">M Al Moaiqel</name></author><author><name sortKey="Al Oudah, N" uniqKey="Al Oudah N">N Al Oudah</name></author><author><name sortKey="Al Ajlan, A" uniqKey="Al Ajlan A">A Al Ajlan</name></author><author><name sortKey="Aljohani, S" uniqKey="Aljohani S">S AlJohani</name></author><author><name sortKey="Alsolamy, S" uniqKey="Alsolamy S">S Alsolamy</name></author><author><name sortKey="Gmati, Ge" uniqKey="Gmati G">GE Gmati</name></author><author><name sortKey="Balkhy, H" uniqKey="Balkhy H">H 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Cervantes-Barragan</name></author><author><name sortKey="Habjan, M" uniqKey="Habjan M">M Habjan</name></author><author><name sortKey="Maier, R" uniqKey="Maier R">R Maier</name></author><author><name sortKey="Neuman, Bw" uniqKey="Neuman B">BW Neuman</name></author><author><name sortKey="Ziebuhr, J" uniqKey="Ziebuhr J">J Ziebuhr</name></author><author><name sortKey="Szretter, Kj" uniqKey="Szretter K">KJ Szretter</name></author><author><name sortKey="Baker, Sc" uniqKey="Baker S">SC Baker</name></author><author><name sortKey="Barchet, W" uniqKey="Barchet W">W Barchet</name></author><author><name sortKey="Diamond, Ms" uniqKey="Diamond M">MS Diamond</name></author><author><name sortKey="Siddell, Sg" uniqKey="Siddell S">SG Siddell</name></author><author><name sortKey="Ludewig, B" uniqKey="Ludewig B">B Ludewig</name></author><author><name sortKey="Thiel, V" uniqKey="Thiel V">V Thiel</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Arizona</li></region></list><tree><country name="États-Unis"><region name="Arizona"><name sortKey="Nikolich Zugich, Janko" sort="Nikolich Zugich, Janko" uniqKey="Nikolich Zugich J" first="Janko" last="Nikolich-Zugich">Janko Nikolich-Zugich</name></region><name sortKey="Bhattacharya, Deepta" sort="Bhattacharya, Deepta" uniqKey="Bhattacharya D" first="Deepta" last="Bhattacharya">Deepta Bhattacharya</name><name sortKey="Fain, Mindy J" sort="Fain, Mindy J" uniqKey="Fain M" first="Mindy J." last="Fain">Mindy J. Fain</name><name sortKey="Knox, Kenneth S" sort="Knox, Kenneth S" uniqKey="Knox K" first="Kenneth S." last="Knox">Kenneth S. Knox</name><name sortKey="Knox, Kenneth S" sort="Knox, Kenneth S" uniqKey="Knox K" first="Kenneth S." last="Knox">Kenneth S. Knox</name><name sortKey="Natt, Bhupinder" sort="Natt, Bhupinder" uniqKey="Natt B" first="Bhupinder" last="Natt">Bhupinder Natt</name><name sortKey="Rios, Carlos Tafich" sort="Rios, Carlos Tafich" uniqKey="Rios C" first="Carlos Tafich" last="Rios">Carlos Tafich Rios</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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